Atypical multiple sclerosis: MRI findings and differential diagnosis

Neurol Sci. 2004 Nov;25 Suppl 4:S356-60. doi: 10.1007/s10072-004-0340-2.


In the past few years, magnetic resonance imaging (MRI) has become increasingly relevant in the diagnosis of multiple sclerosis (MS). Yet, the specificity of MR is limited. Atypical forms of MS and other diseases of the central nervous system may show similar patterns in MR. We briefly discuss the MR findings of the main MS-like diseases. Correct differential diagnosis can be carried out by combining the MR findings with clinical and laboratory findings.

Publication types

  • Review

MeSH terms

  • Brain / pathology*
  • Brain Mapping
  • Brain Neoplasms / pathology
  • Demyelinating Diseases / pathology
  • Diagnosis, Differential
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Multiple Sclerosis / diagnosis*
  • Neurologic Examination
  • Sensitivity and Specificity
  • Vascular Diseases / pathology