Nasal polyposis and its impact on quality of life: comparison between the effects of medical and surgical treatments

Allergy. 2005 Apr;60(4):452-8. doi: 10.1111/j.1398-9995.2005.00725.x.


Background: Nasal polyposis (NP) is not a life-threatening disorder but may have a great impact on the quality of life (QoL). The objective of this study: (i) to investigate the health burden incurred by NP compared with the Spanish general population using the Short Form-36 Health Survey (SF-36) questionnaire; (ii) to compare the QoL outcome after medical or surgical treatment; and (iii) to assess and compare the effect of medical and surgical treatment on nasal symptoms.

Methods: About 109 patients with nasal polyps were included. Fifty-three patients were randomly allocated to receive oral prednisone for 2 weeks and 56 to undergo endoscopic sinus surgery. All patients administered intranasal budesonide for 12 months. Patients were evaluated for nasal symptoms, polyp size, and QoL.

Results: In comparison with the Spanish general population, patients with NP had worse scores on all SF-36 domains except for physical functioning. Nonasthmatic patients with NP had better QoL than asthmatic patients with NP on role physical functioning, body pain, and vitality (P <0.05). At 6 and 12 months, a significant improvement on all of SF-36 domains was observed after both medical and surgical treatment reaching the levels of general population (P <0.05). Nasal symptoms and polyp size improved after both medical and surgical treatment at 6 and 12 months (P <0.05).

Conclusion: These results suggest that NP has considerable impact on a patient's QoL and that both medical and surgical treatment led to similar effects in improving QoL.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Asthma / complications
  • Endoscopy*
  • Female
  • Glucocorticoids / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Nasal Polyps / diagnostic imaging
  • Nasal Polyps / pathology
  • Nasal Polyps / physiopathology*
  • Nasal Polyps / therapy*
  • Prednisone / therapeutic use*
  • Quality of Life*
  • Surveys and Questionnaires
  • Tomography, X-Ray Computed
  • Treatment Outcome


  • Glucocorticoids
  • Prednisone