Genetic analysis of complex cardiovascular traits in the spontaneously hypertensive rat

Exp Physiol. 2005 May;90(3):273-6. doi: 10.1113/expphysiol.2004.029322. Epub 2005 Feb 22.

Abstract

Identification of the genetic determinants of common diseases is a major challenge for current biomedical research. Combining linkage analyses of essentially monogenic cis-regulated expression phenotypes with oligogenic intermediate physiological phenotypes represents a promising approach for identification of quantitative trait loci at the molecular level. In the present review, a genetic analysis of cardiovascular phenotypes studied at several levels of complexity in rat recombinant inbred strains is described.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Gene Expression Profiling / methods*
  • Genetic Predisposition to Disease / genetics*
  • Hypertension / genetics*
  • Hypertension / metabolism*
  • Phenotype
  • Quantitative Trait Loci / genetics*
  • Rats / genetics*
  • Rats / metabolism*
  • Transcription Factors / genetics*

Substances

  • Transcription Factors