Treatment of Parkinson Disease With Diet-Induced Hyperketonemia: A Feasibility Study

Neurology. 2005 Feb 22;64(4):728-30. doi: 10.1212/01.WNL.0000152046.11390.45.

Abstract

Ketones may bypass the defect in complex I activity implicated in Parkinson disease (PD). Five of seven volunteers with PD were able to prepare a "hyperketogenic" diet at home and adhere to it for 28 days. Substituting unsaturated for saturated fats appeared to prevent cholesterol increases in four volunteers. Unified Parkinson's Disease Rating Scale scores improved in all five during hyperketonemia, but a placebo effect was not ruled out.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3-Hydroxybutyric Acid / metabolism*
  • Acetoacetates / metabolism*
  • Aged
  • Antiparkinson Agents / therapeutic use
  • Cholesterol / blood
  • Combined Modality Therapy
  • Dietary Carbohydrates / administration & dosage
  • Dietary Carbohydrates / adverse effects
  • Dietary Carbohydrates / therapeutic use*
  • Dietary Fats / administration & dosage
  • Dietary Fats / adverse effects
  • Dietary Fats / classification
  • Dietary Fats / therapeutic use*
  • Dietary Proteins / administration & dosage
  • Electron Transport Complex I / metabolism*
  • Energy Metabolism
  • Feasibility Studies
  • Female
  • Humans
  • Hypercholesterolemia / etiology
  • Hypercholesterolemia / prevention & control
  • Ketones / blood*
  • Male
  • Middle Aged
  • Mitochondria / metabolism
  • Neurons / metabolism
  • Outpatients
  • Oxidative Stress
  • Parkinson Disease / diet therapy*
  • Parkinson Disease / drug therapy
  • Parkinson Disease / metabolism
  • Patient Compliance
  • Treatment Outcome
  • Weight Loss

Substances

  • Acetoacetates
  • Antiparkinson Agents
  • Dietary Carbohydrates
  • Dietary Fats
  • Dietary Proteins
  • Ketones
  • acetoacetic acid
  • Cholesterol
  • Electron Transport Complex I
  • 3-Hydroxybutyric Acid