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Clinical Trial
. 2005 Feb 22;64(4):728-30.
doi: 10.1212/01.WNL.0000152046.11390.45.

Treatment of Parkinson Disease With Diet-Induced Hyperketonemia: A Feasibility Study

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Clinical Trial

Treatment of Parkinson Disease With Diet-Induced Hyperketonemia: A Feasibility Study

T B Vanitallie et al. Neurology. .

Abstract

Ketones may bypass the defect in complex I activity implicated in Parkinson disease (PD). Five of seven volunteers with PD were able to prepare a "hyperketogenic" diet at home and adhere to it for 28 days. Substituting unsaturated for saturated fats appeared to prevent cholesterol increases in four volunteers. Unified Parkinson's Disease Rating Scale scores improved in all five during hyperketonemia, but a placebo effect was not ruled out.

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