Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 2005 (272), re3

The TRP Superfamily of Cation Channels


The TRP Superfamily of Cation Channels

Craig Montell. Sci STKE.


The transient receptor potential (TRP) protein superfamily consists of a diverse group of cation channels that bear structural similarities to Drosophila TRP. TRP channels play important roles in nonexcitable cells; however, an emerging theme is that many TRP-related proteins are expressed predominantly in the nervous system and function in sensory physiology. The TRP superfamily is divided into seven subfamilies, the first of which is composed of the "classical" TRPs" (TRPC subfamily). Some TRPCs may be store-operated channels, whereas others appear to be activated by production of diacylglycerol or regulated through an exocytotic mechanism. Many members of a second subfamily (TRPV) function in sensory physiology and respond to heat, changes in osmolarity, odorants, and mechanical stimuli. Two members of the TRPM family function in sensory perception and three TRPM proteins are chanzymes, which contain C-terminal enzyme domains. The fourth and fifth subfamilies, TRPN and TRPA, include proteins with many ankyrin repeats. TRPN proteins function in mechanotransduction, whereas TRPA1 is activated by noxious cold and is also required for the auditory response. In addition to these five closely related TRP subfamilies, which comprise the Group 1 TRPs, members of the two Group 2 TRP subfamilies, TRPP and TRPML, are distantly related to the group 1 TRPs. Mutations in the founding members of these latter subfamilies are responsible for human diseases. Each of the TRP subfamilies are represented by members in worms and flies, providing the potential for using genetic approaches to characterize the normal functions and activation mechanisms of these channels.

Similar articles

  • Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels
    C Montell. Sci STKE 2001 (90), re1. PMID 11752662. - Review
    The transient receptor potential (TRP) protein superfamily consists of a diverse group of Ca(2+) permeable nonselective cation channels that bear structural similarities …
  • Evolutionary Conservation and Changes in Insect TRP Channels
    H Matsuura et al. BMC Evol Biol 9, 228. PMID 19740447.
    The total number of insect TRP family members is 13-14, approximately half that of mammalian TRP family members. As shown for mammalian TRP channels, this may suggest tha …
  • TRP Channels in Disease
    B Nilius et al. Sci STKE 2005 (295), re8. PMID 16077087. - Review
    The mammalian TRP (transient receptor potential) family consists of six main subfamilies termed the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycysti …
  • Transient Receptor Proteins Illuminated: Current Views on TRPs and Disease
    PL Nelson et al. Vet J 187 (2), 153-64. PMID 20347603. - Review
    The transient receptor potential proteins (TRPs) make up a very important family of ion channels responsible for a wide array of cellular functions. Originally identified …
  • Structure-function Relationship of the TRP Channel Superfamily
    G Owsianik et al. Rev Physiol Biochem Pharmacol 156, 61-90. PMID 16634147. - Review
    Transient receptor potential (TRP) channels are involved in the perception of a wide range of physical and chemical stimuli, including temperature and osmolarity changes, …
See all similar articles

Cited by 327 PubMed Central articles

See all "Cited by" articles

MeSH terms

LinkOut - more resources