Nasopharyngeal carcinoma-susceptibility locus is localized to a 132 kb segment containing HLA-A using high-resolution microsatellite mapping

Int J Cancer. 2005 Jul 10;115(5):742-6. doi: 10.1002/ijc.20946.


Nasopharyngeal carcinoma (NPC) is an epithelial tumor uniquely prevalent in southern Chinese. HLA-A2 is associated with NPC. In a previous study, we showed that the genes associated with susceptibility to NPC are primarily located within the HLA-A locus in Taiwanese NPC patients. However, the pathogenic genes causing NPC susceptibility remain unknown. Here, 8 polymorphic microsatellite markers distributed over a 1 megabase region surrounding the HLA-A locus were subjected to genetic analysis for the NPC-susceptibility locus. Statistical studies of associated alleles detected on each microsatellite locus showed that the NPC- susceptibility genes are most likely located between the D6S510 and D6S211 markers within a 132 kb segment containing the HLA-A locus. These results undoubtedly would facilitate the further positional cloning of the NPC-susceptibility locus, which has been elusive for the past 30 years.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carcinoma / ethnology
  • Carcinoma / genetics*
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease*
  • HLA-A Antigens / genetics*
  • Humans
  • Male
  • Microsatellite Repeats*
  • Middle Aged
  • Nasopharyngeal Neoplasms / ethnology
  • Nasopharyngeal Neoplasms / genetics*
  • Taiwan


  • HLA-A Antigens