Taste disorders in healthy "carriers" and "non-carriers" of Candida albicans and in patients with candidosis of the tongue

J Dermatol. 2004 Nov;31(11):890-7. doi: 10.1111/j.1346-8138.2004.tb00622.x.

Abstract

Impairments in taste perception may be caused by a number of factors, including the presence of Candida albicans in the oral cavity. We attempted to establish whether the presence of Candida albicans on the tongue is a cause of taste disorders by studying taste disorders in patients with candidosis of the tongue and in healthy "carriers" and "non-carriers" of C. albicans. Taste disorders and their severity were objectively assessed by the filter-paper disk method in 18 patients with candidosis of the tongue and in 33 healthy "carriers" and 167 healthy "non-carriers" of C. albicans. The gustatory function was re-tested in 7 patients and 8 "carriers" after treatment with topical anti-mycotic medication to detect any improvement. Patients with candidosis of the tongue and "carriers" of C. albicans demonstrated significantly higher incidences (p<0.001) of taste disorders than did "non-carriers". The mean taste threshold of each of the four individual taste qualities was significantly higher in patients with candidosis than in "non-carriers". The average taste threshold was significantly higher in "carriers" than in "non-carriers". Post-treatment improvement or recovery from taste disorders was obtained in 5 out of 7 patients (71.4%) with candidosis and in 7 out of 8 "carriers" (87.5%) of C. albicans. This study clearly demonstrates that not only overt candidosis of the tongue but also commensal harboring of C. albicans is a cause of taste disorders.

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / therapeutic use
  • Candida albicans / isolation & purification
  • Candidiasis, Oral / complications*
  • Candidiasis, Oral / drug therapy
  • Carrier State / microbiology*
  • Child
  • Female
  • Humans
  • Male
  • Middle Aged
  • Sex Factors
  • Taste / drug effects
  • Taste / physiology
  • Taste Disorders / microbiology*
  • Taste Threshold / drug effects
  • Taste Threshold / physiology
  • Tongue / microbiology
  • Tongue Diseases / drug therapy
  • Tongue Diseases / microbiology*

Substances

  • Antifungal Agents