Lunasin: a cancer-preventive soy peptide

Nutr Rev. 2005 Jan;63(1):16-21. doi: 10.1111/j.1753-4887.2005.tb00106.x.

Abstract

Lunasin is a novel, cancer-preventive peptide whose efficacy against chemical carcinogens and oncogenes has been demonstrated in mammalian cells and in a skin cancer mouse model. Isolated and characterized in soy, lunasin peptide is also documented in barley. Lunasin is found in all of the genotypes analyzed from the US soy germ plasm collection and in commercially available soy proteins. Pilot studies show that lunasin is bioavailable in mice and rats when orally ingested, opening the way for dietary administration in cancer prevention studies. Lunasin internalizes into mammalian cells within minutes of exogenous application, and localizes in the nucleus after 18 hours. It inhibits acetylation of core histones in mammalian cells. In spite of its cancer-preventive properties, lunasin does not affect the growth rate of normal and established cancer cell lines. An epigenetic mechanism of action is proposed whereby lunasin selectively kills cells being transformed or newly transformed by binding to deacetylated core histones exposed by the transformation event, disrupting the dynamics of histone acetylation-deacetylation and leading to cell death.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Anticarcinogenic Agents* / metabolism
  • Anticarcinogenic Agents* / pharmacology
  • Biological Availability
  • Humans
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / prevention & control*
  • Soybean Proteins* / genetics
  • Soybean Proteins* / metabolism
  • Soybean Proteins* / pharmacology
  • United States

Substances

  • Anticarcinogenic Agents
  • GM2S-1 protein, Glycine max
  • Soybean Proteins