Genetics of lupus nephritis

Lupus. 2005;14(1):2-12. doi: 10.1191/0961203305lu2052oa.


Susceptibility to lupus nephritis is the end-result of complex interactions between polymorphic genetic factors involved in the regulation of immune responses. In humans, genome-wide screens and candidate-gene analyses led to the identification of several loci containing potential targets (FcgammaRIIa, PTPN22, PD-1, IL-10) for physiopathological research and therapeutic interventions. In mice, the generation of congenic mice, bearing in a normal genetic background one single disease-associated locus, greatly improved our understanding of the mechanisms mediating the genetic contribution to the disease. In the future, the identification of disease-associated genes will open new perspectives for the development of more targeted therapies of lupus nephritis.

Publication types

  • Review

MeSH terms

  • Animals
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Humans
  • Lupus Nephritis / genetics*
  • Lupus Nephritis / immunology
  • Mice
  • Models, Animal