Treatment outcome of multidrug-resistant tuberculosis among Vietnamese immigrants

Int J Tuberc Lung Dis. 2005 Feb;9(2):164-9.

Abstract

Objective: To review the outcome for MDR-TB treatment among potential migrants from Vietnam.

Setting: All cases of documented MDR-TB treated by the International Organization of Migration (IOM) in Vietnam from 1989 to 2000 were reviewed.

Methods: MDR-TB was defined as isoniazid- and rifampicin-resistant Mycobacterium tuberculosis. All cases of TB treated by the IOM and recorded in the computerised database were reviewed to identify MDR-TB cases. Demographics, chest radiograph results, drug resistance, drug use and dosage, duration of treatment, and outcome were analysed.

Results: Forty-four cases of MDR-TB were identified. Treatment consisted of ambulatory directly observed treatment with an 8-drug protocol: isoniazid, rifampicin, pyrazinamide, ethambutol, capreomycin, ethionamide, ofloxacin and cycloserine. This initial protocol was modified due to drug availability or drug intolerance. Patients were treated with a median of 8 drugs (range 6-12). Mean duration of treatment for MDR-TB was 23.0 (SD+/-11.4) months. Thirty-eight (86%) patients were cured and emigrated, one failed treatment (2%), three were lost to follow-up (7%) and two died (4%).

Conclusion: Treatment for MDR-TB provided by the IOM was effective in preparing a low-income population for migration.

MeSH terms

  • Capreomycin / administration & dosage
  • Cycloserine / administration & dosage
  • Drug Therapy, Combination
  • Emigration and Immigration*
  • Ethambutol / administration & dosage
  • Ethionamide / administration & dosage
  • Female
  • Humans
  • Isoniazid / administration & dosage
  • Male
  • Middle Aged
  • Ofloxacin / administration & dosage
  • Pyrazinamide / administration & dosage
  • Rifampin / administration & dosage
  • Treatment Outcome
  • Tuberculosis, Multidrug-Resistant / drug therapy*
  • Vietnam / ethnology

Substances

  • Capreomycin
  • Pyrazinamide
  • Ethambutol
  • Cycloserine
  • Ofloxacin
  • Ethionamide
  • Isoniazid
  • Rifampin