A new lipase in regulating lipid mobilization: hormone-sensitive lipase is not alone

Trends Endocrinol Metab. 2005 Mar;16(2):35-6. doi: 10.1016/j.tem.2005.01.009.

Abstract

Three papers recently appeared simultaneously that identify a new triacylglycerol lipase. Zimmerman et al. identified this lipase as adipocyte triacylglycerol lipase (ATGL). Jenkins et al. identified it as the zeta-isoform of a calcium-independent phospholipase A(2) (iPLA(2)), whereas Villena et al. found this enzyme and called it desnutrin. Interestingly, if, as implied, this lipase works in concert with hormone-sensitive lipase, then our concept of regulated fatty acid mobilization from triacylglycerols will have to be revised.

MeSH terms

  • Animals
  • Biological Transport / physiology
  • Carboxylic Ester Hydrolases / physiology*
  • Group VI Phospholipases A2
  • Humans
  • Isoenzymes / physiology
  • Lipase / physiology*
  • Lipid Metabolism*
  • Mice
  • Phospholipases A / physiology*
  • Sterol Esterase / physiology*
  • Terminology as Topic

Substances

  • Isoenzymes
  • Carboxylic Ester Hydrolases
  • Sterol Esterase
  • Lipase
  • PNPLA2 protein, mouse
  • Phospholipases A
  • Group VI Phospholipases A2
  • PLA2G6 protein, human
  • Pla2g6 protein, mouse