Secondary generalized dystonia without basal ganglia damage

Parkinsonism Relat Disord. 2005 Mar;11(2):121-3. doi: 10.1016/j.parkreldis.2004.08.007.


We report the case of a woman who developed generalized dystonia, severe cognitive deficits and dysphagia following an overdose of the hypoglycaemic drug, sulphonylurea. The MRI reveals frontal and temporal lobe atrophy, but no evidence of damage to the basal ganglia. This case adds to the small number of previously reported cases with secondary dystonia seemingly due to cortical rather than subcortical damage.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Basal Ganglia*
  • Deglutition Disorders / chemically induced
  • Deglutition Disorders / pathology
  • Dystonia / chemically induced*
  • Dystonia / pathology*
  • Female
  • Frontal Lobe / pathology
  • Humans
  • Hypoglycemic Agents / poisoning*
  • Magnetic Resonance Imaging
  • Suicide, Attempted
  • Sulfonylurea Compounds / poisoning*
  • Temporal Lobe / pathology


  • Hypoglycemic Agents
  • Sulfonylurea Compounds