Sex and death: what is the connection?

Cell. 2005 Feb 25;120(4):461-72. doi: 10.1016/j.cell.2005.01.026.


A cost of reproduction, where lifespan and fecundity are negatively correlated, is of widespread occurrence. Mutations in insulin/IGF signaling (IIS) pathways and dietary restriction (DR) can extend lifespan in model organisms but do not always reduce fecundity, suggesting that the link between lifespan and fecundity is not inevitable. Understanding the molecular basis of the cost of reproduction will be informed by elucidation of the mechanisms by which DR and IIS affect these two traits.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Caloric Restriction
  • Humans
  • Insulin / genetics
  • Insulin / physiology*
  • Insulin-Like Growth Factor I / genetics
  • Insulin-Like Growth Factor I / physiology*
  • Longevity / genetics
  • Longevity / physiology*
  • Mutation / genetics
  • Mutation / physiology
  • Reproduction / genetics
  • Reproduction / physiology*


  • Insulin
  • Insulin-Like Growth Factor I