Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 120 (4), 483-95

Mitochondria, Oxidants, and Aging


Mitochondria, Oxidants, and Aging

Robert S Balaban et al. Cell.


The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. Numerous cell culture, invertebrate, and mammalian models exist that lend support to this half-century-old hypothesis. Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging.

Similar articles

  • The Role of Oxidative Damage and Stress in Aging
    A Bokov et al. Mech Ageing Dev 125 (10-11), 811-26. PMID 15541775. - Review
    The Free Radical/Oxidative Stress Theory of Aging, which was first proposed in 1956, is currently one of the most popular explanations for how aging occurs at the biochem …
  • The Aging Brain, Metals and Oxygen Free Radicals
    FE Samson et al. Cell Mol Biol (Noisy-le-grand) 46 (4), 699-707. PMID 10875433. - Review
    In this overview we bring together certa in facts and concepts that support the theory that the aging of "disease-free" brain is a consequence of the accumulated cellular …
  • [Ageing Free Radicals and Cellular Stress]
    R Barouki. Med Sci (Paris) 22 (3), 266-72. PMID 16527207. - Review
    A number of theories have attempted to account for ageing processes in various species. Following the << rate of living >> theory of Pearl, Harman suggested f …
  • [The Role of Reactive Oxygen Species and Mitochondria in Aging]
    A Piotrowska et al. Postepy Biochem 60 (2), 240-7. PMID 25134359. - Review
    Aging is a biological phenomenon concerning all living multicellular organisms. Many studies have been conducted to identify the mechanisms underlying this process. To da …
  • Ageing and Free Radicals
    JM Gutteridge. Med Lab Sci 49 (4), 313-8. PMID 1339935.
    Mammalian ageing is a universal phenomenon that is both obvious and inevitable, yet poorly understood, and under-researched at the molecular level. Numerous ageing theori …
See all similar articles

Cited by 1,173 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources