Medical Conditions Increasing the Risk of Chronic Thromboembolic Pulmonary Hypertension

Thromb Haemost. 2005 Mar;93(3):512-6. doi: 10.1160/TH04-10-0657.

Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by organized thromboemboli that obstruct the pulmonary vascular bed. Although CTEPH is a serious complication of acute symptomatic pulmonary embolism in 4% of cases, signs, symptoms and classical risk factors for venous thromboembolism are lacking. The aim of the present study was to identify medical conditions conferring an increased risk of CTEPH. We performed a case-control-study comparing 109 consecutive CTEPH patients to 187 patients with acute pulmonary embolism that was confirmed by a high probability lung scan. Splenectomy (odds ratio=13, 95% CI 2.7-127), ventriculo-atrial (VA-) shunt for the treatment of hydrocephalus (odds ratio=13, 95% CI 2.5-129) and chronic inflammatory disorders, such as osteomyelitis and inflammatory bowel disease (IBD, odds ratio=67, 95% CI 7.9-8832) were associated with an increased risk of CTEPH.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arteriovenous Shunt, Surgical / adverse effects
  • Case-Control Studies
  • Chronic Disease
  • Female
  • Humans
  • Hydrocephalus / therapy
  • Hypertension, Pulmonary / etiology*
  • Inflammation / complications
  • Inflammation / physiopathology
  • Inflammatory Bowel Diseases / complications
  • Inflammatory Bowel Diseases / physiopathology
  • Male
  • Middle Aged
  • Odds Ratio
  • Osteomyelitis / complications
  • Osteomyelitis / physiopathology
  • Pulmonary Embolism*
  • Risk
  • Splenectomy / adverse effects
  • Thromboembolism