Transglutaminase function in epidermis

J Invest Dermatol. 2005 Mar;124(3):481-92. doi: 10.1111/j.0022-202X.2005.23627.x.


Surface epithelial cells, such as the epidermal keratinocyte, undergo a process of terminal cell differentiation that results in the construction of a multilayered epithelium. This epithelium functions to protect the organism from the environment. Transglutaminases, enzymes that catalyze the formation of isopeptide protein-protein cross-links, are key enzymes involved in the construction of this structure. This brief review will focus on the role of these enzymes in constructing the epidermal surface.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Epidermal Cells
  • Epidermis / enzymology*
  • Humans
  • Keratinocytes / cytology
  • Keratinocytes / enzymology*
  • Transglutaminases / physiology*


  • Transglutaminases