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. 2005 Apr 8;329(2):789-95.
doi: 10.1016/j.bbrc.2005.01.157.

Enhanced Bone Regeneration With a Synthetic Cell-Binding Peptide--In Vivo Results

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Enhanced Bone Regeneration With a Synthetic Cell-Binding Peptide--In Vivo Results

Michael Thorwarth et al. Biochem Biophys Res Commun. .

Abstract

This in vivo study compared the regenerative processes within defined defects of the porcine skull after delivery of a porous algae-derived hydroxyapatite (adHA), a similar, experimental adHA carrying the cell binding peptide P-15, used solely and in combination with 25% autogenous bone (AB). Particulated AB served as a control group. During an observation period of 26 weeks, microradiography and histology were performed at four specific times. Significantly higher mineralization rates (p=0.008) were found 4 weeks after application of the bioactive material in combination with AB. At 12 weeks there was a significantly higher mineralization (p=0.036) following the application of the bioactive form alone. This study showed significantly higher mineralization after use of a P-15 bioactivated material at early stages. Thus, it can be concluded that the application of the P-15 sequence to an hydroxyapatite accelerates the process of early bone formation, whereas no long-term effect was traced.

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