Stress-induced immune dysfunction: implications for health

Nat Rev Immunol. 2005 Mar;5(3):243-51. doi: 10.1038/nri1571.


Folk wisdom has long suggested that stressful events take a toll on health. The field of psychoneuroimmunology (PNI) is now providing key mechanistic evidence about the ways in which stressors--and the negative emotions that they generate--can be translated into physiological changes. PNI researchers have used animal and human models to learn how the immune system communicates bidirectionally with the central nervous and endocrine systems and how these interactions impact on health.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / immunology
  • Animals
  • Central Nervous System / immunology
  • Communicable Diseases / etiology
  • Communicable Diseases / immunology
  • Endocrine System / immunology
  • Humans
  • Immune System / physiopathology*
  • Inflammation / etiology
  • Inflammation / immunology
  • Models, Immunological
  • Stress, Physiological / immunology*
  • Wound Healing / immunology