The promise of genetically engineered mice for cancer prevention studies

Nat Rev Cancer. 2005 Mar;5(3):184-98. doi: 10.1038/nrc1565.


Sophisticated genetic technologies have led to the development of mouse models of human cancers that recapitulate important features of human oncogenesis. Many of these genetically engineered mouse models promise to be very relevant and relatively rapid systems for determining the efficacy of chemopreventive agents and their mechanisms of action. The validation of such models for chemoprevention will help the selection of appropriate agents for large-scale clinical trials and allow the testing of combination therapies.

Publication types

  • Review

MeSH terms

  • Animals
  • Animals, Genetically Modified*
  • Antineoplastic Agents / pharmacology
  • Chemoprevention*
  • Colonic Neoplasms / genetics
  • Colonic Neoplasms / veterinary
  • Disease Models, Animal*
  • Humans
  • Mammary Neoplasms, Experimental / genetics
  • Mice
  • Neoplasms / genetics*
  • Neoplasms / prevention & control*


  • Antineoplastic Agents