Organization of vesicular trafficking in epithelia

Nat Rev Mol Cell Biol. 2005 Mar;6(3):233-47. doi: 10.1038/nrm1593.


Experiments using mammalian epithelial cell lines have elucidated biosynthetic and recycling pathways for apical and basolateral plasma-membrane proteins, and have identified components that guide apical and basolateral proteins along these pathways. These components include apical and basolateral sorting signals, adaptors for basolateral signals, and docking and fusion proteins for vesicular trafficking. Recent live-cell-imaging studies provide a real-time view of sorting processes in epithelial cells, including key roles for actin, microtubules and motors in the organization of post-Golgi trafficking.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adaptor Proteins, Vesicular Transport / physiology
  • Animals
  • Cell Membrane / physiology
  • Cytoplasmic Vesicles / physiology*
  • Cytoskeleton / physiology
  • Dogs
  • Epithelium / physiology*
  • Kidney / physiology
  • Signal Transduction / physiology*


  • Adaptor Proteins, Vesicular Transport