Do peptides control their own birth and death?

Nat Rev Mol Cell Biol. 2005 Mar;6(3):263-7. doi: 10.1038/nrm1590.

Abstract

The tumour suppressor protein p53 and the Epstein-Barr-virus-encoded Epstein-Barr virus nuclear antigen-1 (EBNA1) can regulate their own proteasomal degradation and mRNA translation - in effect, they mediate control of their own steady-state levels. A large fraction of mRNA-translation-initiation events does not give rise to functional proteins; so could this reflect a more widespread concept by which certain proteins that require tight control of expression use similar means of self-regulation?

MeSH terms

  • Epstein-Barr Virus Nuclear Antigens / genetics
  • Epstein-Barr Virus Nuclear Antigens / metabolism*
  • Herpesvirus 4, Human / genetics
  • Herpesvirus 4, Human / metabolism
  • Homeostasis / physiology*
  • Humans
  • Peptides / genetics
  • Peptides / metabolism*
  • RNA, Messenger / metabolism
  • Ribosomal Proteins / genetics
  • Ribosomal Proteins / metabolism
  • Ribosomes / metabolism
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Epstein-Barr Virus Nuclear Antigens
  • Peptides
  • RNA, Messenger
  • Ribosomal Proteins
  • Tumor Suppressor Protein p53
  • EBV-encoded nuclear antigen 1