Sporadic Creutzfeldt-Jakob disease: a comparison of pathological findings and diffusion weighted imaging

J Neurol. 2005 Mar;252(3):338-42. doi: 10.1007/s00415-005-0648-8. Epub 2005 Mar 3.


To investigate a possible relationship between the severity of pathological and radiological lesions in diffusion-weighted MRI (DWI) we compared DWI findings from 6 sequential brain MRI scans with pathological features of numerous tissue blocks of different cortical and subcortical regions in a case of autopsy-proven sporadic CJD. Whereas DWI and pathological examination revealed multifocal, cortical and deep hyperintensities at corresponding localizations, no correlation between the degree of severity of radiologically visible and pathological damage was found. The characteristic focal involvement and extension of lesions of the cortex and the basal ganglia bilaterally shown by DWI may be an argument for the spreading of the disease per contiguitatem.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Cell Death
  • Creutzfeldt-Jakob Syndrome / diagnostic imaging
  • Creutzfeldt-Jakob Syndrome / pathology*
  • Diffusion Magnetic Resonance Imaging*
  • Disease Progression
  • Female
  • Gliosis / etiology
  • Humans
  • Middle Aged
  • Radiography
  • Radiology / methods
  • Time Factors