Screening of chemical composition and antifungal and antioxidant activities of the essential oils from three Turkish artemisia species

J Agric Food Chem. 2005 Mar 9;53(5):1408-16. doi: 10.1021/jf048429n.


The compositions of essential oils isolated from the aerial parts of Artemisia absinthium, Artemisia santonicum, and Artemisia spicigera by hydrodistillation were analyzed by GC-MS, and a total of 204 components were identified. The major components of these essential oils were camphor (34.9-1.4%), 1,8-cineole (9.5-1.5%), chamazulene (17.8-nd%), nuciferol propionate (5.1-nd%), nuciferol butanoate (8.2-nd%), caryophyllene oxide (4.3-1.7%), borneol (5.1-0.6%), alpha-terpineol (4.1-1.6%), spathulenol (3.7-1.3%), cubenol (4.2-0.1%), beta-eudesmol (7.2-0.6%), and terpinen-4-ol (3.5-1.2%). The antifungal activities of these essential oils were tested against 11 plant fungi and were compared with that of a commercial antifungal reagent, benomyl. The results showed that all of the oils have potent inhibitory effects at very broad spectrum against all of the tested fungi. Pure camphor and 1,8-cineole, which are the major components of the oils, were also tested for antifungal activity against the same fungal species. Unlike essential oils, these pure compounds were able to show antifungal activity against only some of the fungal species. In addition, the antioxidant and DPPH radical scavenging activities of the essential oils, camphor, and 1,8-cineole were determined in vitro. All of the studied essential oils showed antioxidant activity, but camphor and 1,8-cineole did not.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / analysis*
  • Antioxidants / pharmacology
  • Artemisia / chemistry*
  • Azulenes
  • Benomyl / pharmacology
  • Biphenyl Compounds
  • Camphor / analysis
  • Camphor / pharmacology
  • Cycloheptanes / analysis
  • Cyclohexanols / analysis
  • Cyclohexanols / pharmacology
  • Eucalyptol
  • Fungicides, Industrial / analysis*
  • Fungicides, Industrial / pharmacology
  • Gas Chromatography-Mass Spectrometry
  • Monoterpenes / analysis
  • Monoterpenes / pharmacology
  • Oils, Volatile / chemistry*
  • Oils, Volatile / pharmacology
  • Picrates
  • Turkey


  • Antioxidants
  • Azulenes
  • Biphenyl Compounds
  • Cycloheptanes
  • Cyclohexanols
  • Fungicides, Industrial
  • Monoterpenes
  • Oils, Volatile
  • Picrates
  • Camphor
  • 1,1-diphenyl-2-picrylhydrazyl
  • Eucalyptol
  • Benomyl
  • chamazulene