A comparison of electronic monitoring vs. clinician rating of antipsychotic adherence in outpatients with schizophrenia

Psychiatry Res. 2005 Feb 28;133(2-3):129-33. doi: 10.1016/j.psychres.2004.11.002.


Antipsychotic non-adherence rates of outpatients with schizophrenia or schizoaffective disorder was assessed by electronic monitoring and clinician rating. Antipsychotic adherence was determined monthly over 3 consecutive months with (1) the Medication Event Monitoring System (MEMS) cap and (2) the Clinician Rating Scale. Non-adherence was defined as daily adherence of <70% during any one of three monthly evaluations for MEMS and ratings of <or=4 (scale of 1-7) on the Clinician Rating Scale. Non-adherence was detected in 12 of 25 patients (48%) by MEMS and 0% by the Clinician Rating Scale. Clinician assessment dramatically underestimated antipsychotic non-adherence.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Ambulatory Care
  • Antipsychotic Agents / therapeutic use*
  • Drug Monitoring / instrumentation*
  • Electronics / methods*
  • Female
  • Humans
  • Male
  • Medication Systems
  • Observer Variation
  • Patient Compliance / statistics & numerical data*
  • Schizophrenia / drug therapy*


  • Antipsychotic Agents