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Comparative Study
. 2005 Mar;162(3):599-601.
doi: 10.1176/appi.ajp.162.3.599.

Association between reduced extraversion and right posterior fusiform gyrus gray matter reduction in chronic schizophrenia

Toshiaki Onitsuka  1 , Paul G Nestor, Ronald J Gurrera, Martha E Shenton, Kiyoto Kasai, Melissa Frumin, Margaret A Niznikiewicz, Robert W McCarley
Affiliations
Comparative Study

Association between reduced extraversion and right posterior fusiform gyrus gray matter reduction in chronic schizophrenia

Toshiaki Onitsuka et al. Am J Psychiatry. 2005 Mar.

Abstract

Objective: The authors examined the association between volume of the fusiform gyrus, a region involved in face processing, and the personality trait of extraversion in patients with schizophrenia.

Method: Male patients (N=24) and age-matched male comparison subjects (N=26) completed NEO Five-Factor Inventory personality measures of extraversion and underwent high-spatial-resolution magnetic resonance imaging of anterior and posterior fusiform gyrus gray matter.

Results: Low extraversion scores were significantly correlated with gray matter volume reductions in the right posterior fusiform gyrus for patients but not comparison subjects.

Conclusions: Reduced right posterior fusiform gyrus volume may contribute to disease-related social disturbances, characterized by both low extraversion and reduced sensitivity to human faces.

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Figures

FIGURE 1
FIGURE 1
Delineation of the Anterior and Posterior Fusiform Gyrus Regions of Interest
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