Antioxidant activity of Ganoderma lucidum in acute ethanol-induced heart toxicity

Phytother Res. 2004 Dec;18(12):1024-6. doi: 10.1002/ptr.1557.


The hot water extract of the mushroom Ganoderma lucidum was shown to have antioxidative effect against heart toxicity. Investigations into the mechanisms of action, level of lipid peroxidation level in vivo, and superoxide scavenging activity were also conducted. The mice were divided into six groups with ten animals in each group. Ganoderma lucidum, at doses of 10, 25 and 50 mg/kg (p.o.) was administered. Superoxide anions were assayed by UV spectrophotometer using the cytochrome C reduction method. The results of this study showed that Ganoderma lucidum exhibited a dose-dependent antioxidative effect on lipid peroxidation and superoxide scavenging activity in mouse heart homogenate. Additionally, this result indicated that heart damage induced by ethanol shows a higher malonic dialdehyde level compared with heart homogenate treated with Ganoderma lucidum. It is concluded that the antioxidative activity may therefore contribute to the cardioprotective effect of Ganoderma lucidum, and may therefore protect the heart from superoxide induced damage.

MeSH terms

  • Administration, Oral
  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology*
  • Antioxidants / therapeutic use
  • Cardiotonic Agents / administration & dosage
  • Cardiotonic Agents / pharmacology*
  • Cardiotonic Agents / therapeutic use
  • Ethanol
  • Free Radical Scavengers / administration & dosage
  • Free Radical Scavengers / pharmacology
  • Free Radical Scavengers / therapeutic use
  • Heart Diseases / chemically induced
  • Heart Diseases / prevention & control*
  • Lipid Peroxidation / drug effects
  • Male
  • Mice
  • Mice, Inbred ICR
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Reishi*
  • Superoxides / metabolism
  • Thiobarbituric Acid Reactive Substances / metabolism


  • Antioxidants
  • Cardiotonic Agents
  • Free Radical Scavengers
  • Plant Extracts
  • Thiobarbituric Acid Reactive Substances
  • Superoxides
  • Ethanol