Orofacial manifestations of mixed connective tissue disease with an uncommon serologic evolution

Oral Surg Oral Med Oral Pathol. 1992 Apr;73(4):441-4. doi: 10.1016/0030-4220(92)90321-g.


Mixed connective tissue disease is a multisystemic disorder with overlapping features of systemic lupus erythematosus, scleroderma, and polymyositis, and is differentiated from them by a high titer of antibody to ribonucleoprotein. Orofacial manifestations of mixed connective tissue disease include trigeminal neuralgia-like pain, neuropathy, features suggestive of Sjögren's syndrome, and lymphadenopathy. Our recent experience with one patient with trigeminal neuropathy, facial paralysis, Sjögren's syndrome, and aseptic meningitis as early manifestations of the disease, together with an uncommon serologic evolution, is described.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Antinuclear / analysis
  • Diagnosis, Differential
  • Facial Pain / pathology*
  • Facial Paralysis / pathology*
  • Female
  • Humans
  • Meningitis, Aseptic / pathology
  • Mixed Connective Tissue Disease / pathology*
  • Ribonucleoproteins / immunology
  • Sjogren's Syndrome / pathology
  • Trigeminal Neuralgia / pathology*


  • Antibodies, Antinuclear
  • Ribonucleoproteins