Treatment of depression improves physical functioning in older adults

J Am Geriatr Soc. 2005 Mar;53(3):367-73. doi: 10.1111/j.1532-5415.2005.53151.x.


Objectives: To determine the effect of collaborative care management for depression on physical functioning in older adults.

Design: Multisite randomized clinical trial.

Setting: Eighteen primary care clinics from eight healthcare organizations.

Participants: One thousand eight hundred one patients aged 60 and older with major depressive disorder.

Intervention: Patients were randomized to the Improving Mood: Promoting Access to Collaborative Treatment (IMPACT) intervention (n=906) or to a control group receiving usual care (n=895). Control patients had access to all health services available as part of usual care. Intervention patients had access for 12 months to a depression clinical specialist who coordinated depression care with their primary care physician.

Measurements: The 12-item short form Physical Component Summary (PCS) score (range 0-100) and instrumental activities of daily living (IADLs) (range 0-7).

Results: The mean patient age was 71.2, 65% were women, and 77% were white. At baseline, the mean PCS was 40.2, and the mean number of IADL dependencies was 0.7; 45% of participants rated their health as fair or poor. Intervention patients experienced significantly better physical functioning at 1 year than usual-care patients as measured using between-group differences on the PCS of 1.71 (95% confidence interval (CI)=0.96-2.46) and IADLs of -0.15 (95% CI=-0.29 to -0.01). Intervention patients were also less likely to rate their health as fair or poor (37.3% vs 52.4%, P<.001). Combining both study groups, patients whose depression improved were more likely to experience improvement in physical functioning.

Conclusion: The IMPACT collaborative care model for late-life depression improves physical function more than usual care.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living*
  • Aged
  • Depressive Disorder, Major / classification
  • Depressive Disorder, Major / therapy*
  • Female
  • Geriatrics*
  • Health Status
  • Humans
  • Male
  • Middle Aged
  • Physical Fitness*
  • Severity of Illness Index