Abstract
Intracellular double-stranded (ds) RNA is a major sign of replication for many viruses. Host mechanisms detect the dsRNA and provoke antiviral responses. Recently, we identified retinoic acid inducible gene-I (RIG-I), which encodes a DExD/H box RNA helicase containing the caspase recruitment domain (CARD) as a critical regulator for dsRNA-induced signaling. The helicase domain with intact ATPase activity is responsible for recognition of dsRNA, and the CARD transmits downstream signals, resulting in the activation of genes including type I interferons. In this review, we discuss the function of RIG-I in antiviral innate immunity.
MeSH terms
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Adenosine Triphosphatases
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Animals
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DEAD Box Protein 58
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DEAD-box RNA Helicases
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Gene Expression Regulation, Viral*
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Humans
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Immunity, Innate / immunology*
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Interferon Type I / genetics*
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Promoter Regions, Genetic
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Protein Structure, Tertiary
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RNA Helicases* / chemistry
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RNA Helicases* / genetics
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RNA Helicases* / immunology
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RNA Helicases* / physiology
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RNA, Double-Stranded / immunology
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Receptors, Immunologic
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Receptors, Interferon / physiology
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Signal Transduction / genetics
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Transcription Factors / physiology
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Virus Physiological Phenomena*
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Virus Replication / genetics*
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Virus Replication / immunology*
Substances
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Interferon Type I
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RNA, Double-Stranded
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Receptors, Immunologic
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Receptors, Interferon
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Transcription Factors
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Adenosine Triphosphatases
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RIGI protein, human
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DEAD Box Protein 58
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DEAD-box RNA Helicases
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RNA Helicases