Expression of the polymorphic human DNA repair gene XRCC1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines

Radiat Res. 1992 May;130(2):166-70.


The human X-ray repair cross-complementing gene 1 (XRCC1) is highly polymorphic in the cells of human head and neck squamous cell carcinoma lines and in a variety of other human cell lines. We describe six patterns seen in Southern analysis of EcoRI-digested genomic DNA. Levels of XRCC1 mRNA vary in cells of human head and neck cell lines as seen in northern blots. Expression of this gene in cell culture does not correlate with radiobiological parameters, clinical outcome, or the DNA restriction fragment length polymorphisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blotting, Northern
  • Blotting, Southern
  • Carcinoma, Squamous Cell / genetics*
  • DNA Repair / genetics*
  • DNA Repair / radiation effects
  • Humans
  • RNA, Messenger / analysis*
  • RNA, Neoplasm / analysis*
  • Radiation Tolerance / genetics*
  • Tumor Cells, Cultured


  • RNA, Messenger
  • RNA, Neoplasm