Aspirin use during early pregnancy and the risk of congenital abnormalities: a population-based case-control study

Am J Obstet Gynecol. 2005 Mar;192(3):922-3. doi: 10.1016/j.ajog.2004.10.598.


It is still controversial whether aspirin use during pregnancy increases the risk of certain congenital abnormalities (in particular, neural tube defects, gastroschisis, and cleft lip +/- palate). We examined the risk of selected congenital abnormalities in a large case-control dataset from Hungary and found no increased risk of such congenital abnormalities.

MeSH terms

  • Abnormalities, Drug-Induced / etiology*
  • Aspirin / adverse effects*
  • Case-Control Studies
  • Cleft Lip / chemically induced
  • Cleft Palate / chemically induced
  • Female
  • Fetus / drug effects
  • Gastroschisis / chemically induced
  • Humans
  • Neural Tube Defects / chemically induced
  • Pregnancy


  • Aspirin