Almonds in the diet simultaneously improve plasma alpha-tocopherol concentrations and reduce plasma lipids

J Am Diet Assoc. 2005 Mar;105(3):449-54. doi: 10.1016/j.jada.2004.12.002.


The objective of this study was to assess the dose-response effect of almond intake on plasma and red blood cell tocopherol concentrations in healthy adults enrolled in a randomized, crossover feeding trial. Participants were 16 healthy men and women, aged 41+/-13 years. After a 2-week run-in period, participants were fed three diets for 4 weeks each: a control diet, a low-almond diet, and a high-almond diet, in which almonds contributed 0%, 10%, and 20% of total energy, respectively. Changes in blood tocopherol levels were assayed by high pressure liquid chromatography. Incorporating almonds into the diet helped meet the revised Recommended Dietary Allowance of 15 mg/day alpha-tocopherol and increased lipid-adjusted plasma and red blood cell alpha-tocopherol concentrations. A significant dose-response effect was observed between percent energy in the diet from almonds and plasma ratio of alpha-tocopherol to total cholesterol.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antioxidants / analysis
  • Antioxidants / metabolism
  • Cholesterol / blood*
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Chromatography, High Pressure Liquid
  • Cross-Over Studies
  • Dose-Response Relationship, Drug
  • Erythrocytes / chemistry*
  • Female
  • Humans
  • Male
  • Nutrition Policy
  • Nutritional Requirements
  • Prunus* / chemistry
  • Triglycerides / blood
  • alpha-Tocopherol / analysis
  • alpha-Tocopherol / blood*
  • beta-Tocopherol / blood
  • gamma-Tocopherol / blood


  • Antioxidants
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Triglycerides
  • gamma-Tocopherol
  • Cholesterol
  • beta-Tocopherol
  • alpha-Tocopherol