Vertically acquired neonatal citrobacter brain abscess - case report and review of the literature

J Clin Neurosci. 2005 Feb;12(2):188-90. doi: 10.1016/j.jocn.2004.03.010.

Abstract

Vertically acquired citrobacter meningitis in the neonate is very rare and carries a very high mortality and morbidity. Overall, approximately 30% of neonates with Citrobacter meningitis die and 50% sustain some damage to the CNS. The authors describe a case of a newborn with Citrobacter koseri meningitis with multiple brain abscesses, with a successful outcome following multiple burr-hole aspirations and prolonged antibiotic therapy. An aggressive surgical approach combined with intravenous antibiotics (including imipenems, to which the organism is very sensitive) for a minimum of 4 weeks appears to improve the outcome of infection with this virulent organism.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Brain Abscess / microbiology*
  • Brain Abscess / pathology
  • Brain Abscess / therapy
  • Chloramphenicol / therapeutic use
  • Cilastatin / therapeutic use
  • Citrobacter koseri
  • Drug Therapy, Combination
  • Enterobacteriaceae Infections / pathology
  • Enterobacteriaceae Infections / therapy
  • Enterobacteriaceae Infections / transmission*
  • Humans
  • Imipenem / therapeutic use
  • Infant, Newborn
  • Infant, Newborn, Diseases / microbiology
  • Infant, Newborn, Diseases / pathology
  • Infant, Newborn, Diseases / therapy
  • Infectious Disease Transmission, Vertical*
  • Male
  • Meningitis, Bacterial / microbiology*
  • Meningitis, Bacterial / pathology
  • Meningitis, Bacterial / therapy
  • Suction

Substances

  • Anti-Bacterial Agents
  • Cilastatin
  • Chloramphenicol
  • Imipenem