Angiostatic agents prevent the development of endometriosis-like lesions in the chicken chorioallantoic membrane

Annemiek W Nap; Gerard A J Dunselman; Arjan W Griffioen; Kevin H Mayo; Johannes L H Evers; Patrick G Groothuis

doi:10.1016/j.fertnstert.2004.06.080

Angiostatic agents prevent the development of endometriosis-like lesions in the chicken chorioallantoic membrane

Fertil Steril. 2005 Mar;83(3):793-5. doi: 10.1016/j.fertnstert.2004.06.080.

Authors

Annemiek W Nap¹, Gerard A J Dunselman, Arjan W Griffioen, Kevin H Mayo, Johannes L H Evers, Patrick G Groothuis

Affiliation

¹ Department of Obstetrics and Gynaecology, Research Institute Growth and Development (GROW), Maastricht University and University Hospital, Maastricht, The Netherlands.

PMID: 15749522
DOI: 10.1016/j.fertnstert.2004.06.080

Abstract

A prospective study was performed to determine the effects of the angiostatic compounds anti-hVEGF antibody, TNP-470, endostatin, and anginex on the vascularization and on endometriosis-like lesion formation in the chicken chorioallantoic membrane model. Endometriosis-like lesion formation was significantly impaired after treatment with angiostatic agents, which was associated with decreased vessel densities in the surrounding chorioallantoic membrane and more necrosis in the endometriosis-like lesions.

MeSH terms

Angiogenesis Inhibitors / pharmacology*
Animals
Antibodies / pharmacology
Chick Embryo
Chickens
Chorioallantoic Membrane / blood supply*
Chorioallantoic Membrane / pathology
Cyclohexanes
Endometriosis / prevention & control*
Endostatins / pharmacology
Female
Neovascularization, Pathologic / drug therapy*
Neovascularization, Pathologic / prevention & control
O-(Chloroacetylcarbamoyl)fumagillol
Sesquiterpenes / pharmacology*
Vascular Endothelial Growth Factor A / immunology

Substances

Angiogenesis Inhibitors
Antibodies
Cyclohexanes
Endostatins
Sesquiterpenes
Vascular Endothelial Growth Factor A
O-(Chloroacetylcarbamoyl)fumagillol