Early prognostic factors for disability in multiple sclerosis, a European multicenter study

Acta Neurol Scand. 1992 Mar;85(3):212-8. doi: 10.1111/j.1600-0404.1992.tb04031.x.


The effects of initial clinical variables on short-term prognosis are analyzed in a cross-sectional study of 574 multiple sclerosis patients from 7 centers in 5 European countries. Patients with a primary progressive course had a 2.3 higher mean disability score (EDSS) than the primary remittent group after a mean duration of disease of 6.6 years. High age at onset was associated with a primary progressive course, and was also related to increased risk of a rapid shift to a secondary progressive course. Among the remittent patients without a secondary progressive course a high age at onset was significantly correlated to a higher disability score. In the whole remittent group the presence of pyramidal and cerebellar symptoms at onset predicted both a high disability score and a rapid shift to a secondary progression, while the effect was reverse for sensory and visual symptoms. No difference between the sexes was found.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Disability Evaluation*
  • Europe
  • Female
  • Humans
  • Male
  • Multiple Sclerosis / diagnosis*
  • Neurologic Examination
  • Prognosis
  • Sex Factors