Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome

Oncogene. 2005 May 26;24(23):3847-52. doi: 10.1038/sj.onc.1208518.

Abstract

Transcription factors encoded by the ETS family of genes are central in integrating signals that regulate cell growth and differentiation, stress responses, and tumorigenesis. This study, analysing laser microdissected paired benign and malignant prostate epithelial cells from prostate cancer (CaP) patients (n=114; 228 specimen) by GeneChip and quantitative real-time RT-PCR, identifies ETS-related gene (ERG), a member of the ETS transcription factor family, as the most frequently overexpressed proto-oncogene in the transcriptome of malignant prostate epithelial cells. Combined quantitative expression analysis of ERG with two other genes commonly overexpressed in CaP, AMACR and DD3, revealed overexpression of at least one of these three genes in virtually all CaP specimen (54 of 55). Comprehensive evaluation of quantitative ERG1 expression with clinicopathological features also suggested that ERG1 expression level in prostate tumor cells relative to benign epithelial cells is indicator of disease-free survival after radical prostatectomy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigens, Neoplasm / genetics
  • DNA-Binding Proteins / genetics*
  • Glutathione S-Transferase pi
  • Glutathione Transferase / genetics
  • Humans
  • Isoenzymes / genetics
  • Male
  • Prostatic Neoplasms / genetics*
  • Racemases and Epimerases / genetics
  • Reverse Transcriptase Polymerase Chain Reaction
  • Trans-Activators / genetics*
  • Transcription, Genetic
  • Transcriptional Regulator ERG

Substances

  • Antigens, Neoplasm
  • DNA-Binding Proteins
  • ERG protein, human
  • Isoenzymes
  • Trans-Activators
  • Transcriptional Regulator ERG
  • prostate cancer antigen 3, human
  • GSTP1 protein, human
  • Glutathione S-Transferase pi
  • Glutathione Transferase
  • Racemases and Epimerases
  • alpha-methylacyl-CoA racemase