Abstract
A series of 5'-O-glycosyl-uridine and thymidine derivatives have been prepared as potential mimics of sugar nucleotides and nucleotide-diphosphates. These compounds proved not to be inhibitors of bovine beta-1,4-galactosyltransferase although some showed moderate inhibition of Salmonella dTDP-alpha-D-glucose 4,6-dehydratase (RmlB).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biomimetics*
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Cattle
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Diphosphates / chemistry*
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Diphosphates / metabolism
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Glucose / analogs & derivatives*
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Glucose / chemistry
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Glucose / metabolism
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Hydro-Lyases / drug effects
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Hydro-Lyases / metabolism
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Monosaccharides / chemistry*
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Monosaccharides / metabolism
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N-Acetyllactosamine Synthase / drug effects
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N-Acetyllactosamine Synthase / metabolism
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Salmonella enterica / enzymology
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Thymine Nucleotides / chemistry*
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Thymine Nucleotides / metabolism
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Uridine Diphosphate / chemistry*
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Uridine Diphosphate / metabolism
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Uridine Diphosphate Galactose / chemistry*
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Uridine Diphosphate Galactose / metabolism
Substances
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Diphosphates
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Monosaccharides
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Thymine Nucleotides
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deoxythymidine diphosphate-glucose
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Uridine Diphosphate Galactose
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Uridine Diphosphate
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N-Acetyllactosamine Synthase
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Hydro-Lyases
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dTDPglucose 4,6-dehydratase
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Glucose