Expanding Functional Diversity of the Coactivators

Trends Biochem Sci. 2005 Mar;30(3):126-32. doi: 10.1016/j.tibs.2005.01.001.

Abstract

Nuclear receptors (NR) function as ligand-regulated transcription factors that transduce hormonal signals from steroid hormones and other lipophillic ligands. NR-mediated transcription depends on coactivators, a diverse group of proteins that affect the transcriptional machinery in a variety of ways such as via their associated enzymatic activities as histone acetyltransferases, methyltransferases, ubiquitin ligases or as agents that integrate signaling via kinase-signaling pathways. Coactivators have various roles in the transcriptional process (i) as molecules that influence key points in the different stages of transcription, (ii) as integrators of environmental growth-factor and steroid-hormone signals, and (iii) as agents of carcinogenesis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Models, Biological
  • Promoter Regions, Genetic
  • Proteasome Endopeptidase Complex / metabolism
  • RNA Splicing
  • Receptors, Cytoplasmic and Nuclear / chemistry
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Signal Transduction
  • Trans-Activators / chemistry
  • Trans-Activators / metabolism*
  • Transcription, Genetic
  • Ubiquitin / metabolism

Substances

  • Receptors, Cytoplasmic and Nuclear
  • Trans-Activators
  • Ubiquitin
  • Proteasome Endopeptidase Complex