The RIP kinases: crucial integrators of cellular stress

Trends Biochem Sci. 2005 Mar;30(3):151-9. doi: 10.1016/j.tibs.2005.01.003.

Abstract

Since the discovery of the first member ten years ago, the receptor-interacting protein (RIP) family kinases have emerged as essential sensors of cellular stress. The different members integrate both extracellular stress signals transmitted by various cell-surface receptors and signals emanating from intracellular stress. The cascades of events initiated by activated RIPs are complex. Not only are pro-survival, inflammatory and immune responses triggered by RIP kinases via the activation of transcription factors such as NF-kappaB and AP-1, but opposing, death-inducing programs can also be initiated by the RIP kinases. Hence, RIP kinases are crucial regulators of cell survival and cell death.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Apoptosis / physiology
  • Cell Survival / physiology
  • Humans
  • Immunity, Innate
  • Keratinocytes / cytology
  • Keratinocytes / enzymology
  • Mice
  • Models, Biological
  • Molecular Sequence Data
  • NF-kappa B / metabolism
  • Protein-Serine-Threonine Kinases / chemistry
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / physiology*
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Tumor Necrosis Factor-alpha / physiology

Substances

  • NF-kappa B
  • Tumor Necrosis Factor-alpha
  • Protein-Serine-Threonine Kinases