Polytopic proteins: preventing aggregation in the membrane

Curr Biol. 2005 Mar 8;15(5):R169-71. doi: 10.1016/j.cub.2005.02.043.

Abstract

It has been proposed that the aggregation of nascent transmembrane segments of polytopic proteins is prevented by chaperones present in the endoplasmic reticulum membrane; now the first experimental support for this proposal has been reported.

Publication types

  • Review

MeSH terms

  • Carrier Proteins / metabolism
  • Endoplasmic Reticulum / metabolism*
  • Membrane Proteins / biosynthesis
  • Membrane Proteins / metabolism*
  • Models, Biological*
  • Molecular Chaperones / metabolism*
  • Protein Folding
  • Protein Structure, Tertiary / physiology
  • SEC Translocation Channels

Substances

  • Carrier Proteins
  • Membrane Proteins
  • Molecular Chaperones
  • SEC Translocation Channels