Structure-function relationship in the tocopherol transfer protein

Ann N Y Acad Sci. 2004 Dec;1031:332-3. doi: 10.1196/annals.1331.035.


The role of specific amino acid residues in mediating the biochemical functions of tocopherol transfer protein (TTP) was investigated using site-directed mutagenesis and functional assays. These findings further current understanding of TTP mechanism of action and its role in human health.

MeSH terms

  • Carrier Proteins / chemistry*
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology*
  • Humans
  • Liver / chemistry
  • Mutation
  • Structure-Activity Relationship*
  • Vitamin E / metabolism


  • Carrier Proteins
  • alpha-tocopherol transfer protein
  • Vitamin E