Vitamin E in uremia and dialysis patients

Ann N Y Acad Sci. 2004 Dec;1031:348-51. doi: 10.1196/annals.1331.041.

Abstract

Vitamin E therapy (based either on oral supplements or new dialysis methods such as vitamin E-coated hemodialysers) has been suggested to yield a better clinical outcome in hemodialysis (HD) patients than in other populations of patients. Among other factors, the presence of a modified vitamin E status might help to explain this apparently paradoxical response to vitamin E. In this study we investigated 104 regular HD patients. The results indicate that, besides having a low dietary intake, these subjects show some abnormalities in the levels and metabolism of vitamin E, such as a disproportion between plasma tocopherols and lipids, low levels of gamma-T, and CEHC accumulation. Although further studies are needed to confirm the clinical relevance of vitamin E therapy in HD, these findings might lead to recommending a higher vitamin E intake in these patients.

MeSH terms

  • Aged
  • Chromans / blood
  • Diet
  • Female
  • Humans
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / therapy*
  • Lipids / blood
  • Male
  • Middle Aged
  • Renal Dialysis*
  • Vitamin E / administration & dosage
  • Vitamin E / blood
  • Vitamin E / therapeutic use*

Substances

  • Chromans
  • Lipids
  • carboxyethyl-hydroxychroman
  • Vitamin E