Accessory protein function in the DNA polymerase III holoenzyme from E. coli

Bioessays. 1992 Feb;14(2):105-11. doi: 10.1002/bies.950140206.


DNA polymerases which duplicate cellular chromosomes are multiprotein complexes. The individual functions of the many proteins required to duplicate a chromosome are not fully understood. The multiprotein complex which duplicates the Escherichia coli chromosome, DNA polymerase III holoenzyme (holoenzyme), contains a DNA polymerase subunit and nine accessory proteins. This report summarizes our current understanding of the individual functions of the accessory proteins within the holoenzyme, lending insight into why a chromosomal replicase needs such a complex structure.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • DNA Polymerase III / chemistry*
  • Escherichia coli / enzymology*
  • Models, Biological


  • DNA Polymerase III