[Regulation of transcription in different HIV-1 subtypes]

Enferm Infecc Microbiol Clin. 2005 Mar;23(3):156-62. doi: 10.1157/13072166.
[Article in Spanish]


Transcriptional activation of HIV-1 gene expression is controlled in part by the interaction of viral and cellular transcription factors with the HIV-1 long terminal repeat (LTR) sequences. LTR variability among different HIV-1 subtypes could affect LTR binding of either cellular or viral elements, influencing the transcription level. This effect, in turn, may have consequences on the biology of the different HIV-1 clades and on disease progression. In some circumstances, a relationship between replication capacity in vitro and changes in binding sequences for transcription factors located at the LTR has been proven.

Publication types

  • Comparative Study
  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cells, Cultured / virology
  • Gene Expression Regulation, Viral*
  • Gene Products, tat / physiology
  • Genetic Variation
  • HIV Long Terminal Repeat / genetics
  • HIV Long Terminal Repeat / physiology*
  • HIV-1 / classification
  • HIV-1 / genetics*
  • Humans
  • Protein Interaction Mapping
  • Receptors, Thyroid Hormone / metabolism
  • Structure-Activity Relationship
  • T-Lymphocytes / virology
  • Transcription Factors / metabolism
  • Transcription, Genetic*
  • tat Gene Products, Human Immunodeficiency Virus


  • Gene Products, tat
  • Receptors, Thyroid Hormone
  • Transcription Factors
  • tat Gene Products, Human Immunodeficiency Virus