Relation of elevated C-reactive protein and interleukin-6 levels to left atrial size and duration of episodes in patients with atrial fibrillation

Am J Cardiol. 2005 Mar 15;95(6):764-7. doi: 10.1016/j.amjcard.2004.11.032.


Previous studies have demonstrated inflammation to be a risk factor in patients with atrial fibrillation (AF). In this prospective study of 90 patients with persistent and permanent AF and 46 controls, we found increased C-reactive protein (CRP) and interleukin-6 levels in patients with AF compared with controls (p <0.001). Multivariate analysis revealed CRP to be an independent predictor of AF (p = 0.01). Left atrial diameter was positively related to CRP and interleukin-6 (p <0.001, R = 0.37; p <0.001, R = 0.46, respectively) and negatively related to left ventricular function. Interleukin-6 levels were positively related to AF duration before cardioversion (p = 0.02). Elevation of CRP and interleukin-6 suggest a role of inflammation in AF, and the relation of CRP and interleukin-6 to left atrial size and AF duration before cardioversion indicates that inflammation may participate in the process of atrial remodeling.

MeSH terms

  • Aged
  • Atrial Fibrillation / immunology*
  • Atrial Fibrillation / therapy
  • Atrial Function, Left / immunology*
  • C-Reactive Protein / metabolism*
  • Cardiac Volume / immunology*
  • Cardiovascular Diseases / immunology
  • Chronic Disease
  • Comorbidity
  • Electric Countershock
  • Female
  • Humans
  • Inflammation / diagnosis
  • Inflammation / immunology
  • Interleukin-6 / blood*
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Organ Size
  • Prospective Studies
  • Risk Factors


  • Interleukin-6
  • C-Reactive Protein