Wound healing of the ocular surface

Ann Med. 1992 Feb;24(1):19-27. doi: 10.3109/07853899209164141.


Wound healing is a complex, long-lasting regulatory sequence that involves expression of a number of genes, which are active during the individual's development. Some of the phenomena differ from normal tissue turnover and growth only quantitatively. This article reviews the current data on corneal wound healing, with particular reference to mesenchymal matrix proteins and their integrin receptors, to growth factors and to proteolytic enzymes. Some inflammatory mediators are also discussed. The theoretical basis for therapeutic interventions is also discussed briefly, in the light of present knowledge.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Adhesion / physiology
  • Cornea / pathology
  • Cornea / physiopathology
  • Cornea / surgery
  • Corneal Injuries*
  • Epidermal Growth Factor / physiology*
  • Epithelium / pathology
  • Epithelium / physiopathology
  • Extracellular Matrix Proteins / physiology*
  • Eye Injuries / pathology
  • Eye Injuries / physiopathology*
  • Eye Proteins / physiology*
  • Humans
  • Integrins / physiology*
  • Serine Endopeptidases / physiology*
  • Wound Healing / physiology


  • Extracellular Matrix Proteins
  • Eye Proteins
  • Integrins
  • Epidermal Growth Factor
  • Serine Endopeptidases