Embryo aneuploidy screening for unexplained recurrent miscarriage: a minireview

Am J Reprod Immunol. 2005 Apr;53(4):159-65. doi: 10.1111/j.1600-0897.2005.00260.x.


Problem: The aim of this study was to investigate the incidence of chromosomal abnormalities in unexplained recurrent miscarriage (RM) patients and assess the role of pre-implantation genetic diagnosis (PGD) in preventing subsequent pregnancy loss and improving pregnancy outcome.

Method of study: Pre-implantation genetic diagnosis was performed in 241 RM cycles and in 35 cycles in patients undergoing PGD for sex-linked diseases (control group). Chromosomes 13, 16, 18, 21, 22, X and Y were analysed by fluorescence in situ hybridization.

Results: The implantation and pregnancy rates in RM patients were 26.4 and 36.5% versus 20.6 and 29.0% in the control group, respectively. The percentage of abnormal embryos was significantly increased in RM patients compared with controls.

Conclusions: Recurrent miscarriage is associated with a higher incidence of chromosomally abnormal embryos. In vitro fertilization (IVF) plus PGD is an important step in the management of these couples.

Publication types

  • Review

MeSH terms

  • Abortion, Habitual / diagnosis
  • Abortion, Habitual / genetics*
  • Adolescent
  • Adult
  • Aneuploidy*
  • Chromosome Aberrations*
  • Chromosomes, Human / genetics*
  • Cytogenetic Analysis
  • Female
  • Fertilization in Vitro
  • Humans
  • In Situ Hybridization, Fluorescence
  • Middle Aged
  • Pregnancy
  • Preimplantation Diagnosis*