Validity of composite end points in clinical trials

BMJ. 2005 Mar 12;330(7491):594-6. doi: 10.1136/bmj.330.7491.594.


Use of composite end points as the main outcome in randomised trials can hide wide differences in the individual measures. How should you apply the results to clinical practice?

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Endpoint Determination*
  • Humans
  • Randomized Controlled Trials as Topic / standards*
  • Sensitivity and Specificity