Adenovirus-based Genetic Vaccines for Biodefense

Hum Gene Ther. 2005 Feb;16(2):157-68. doi: 10.1089/hum.2005.16.157.

Abstract

The robust host responses elicited against transgenes encoded by (E1-)(E3-) adenovirus (Ad) gene transfer vectors can be used to develop Ad-based vectors as platform technologies for vaccines against potential bioterror pathogens. This review focuses on pathogens of major concern as bioterror agents and why Ad vectors are ideal as anti-bioterror vaccine platforms, providing examples from our laboratories of using Ad vectors as vaccines against potential bioterror pathogens and how Ad vectors can be developed to enhance vaccine efficacy in the bioterror war.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • AIDS Vaccines*
  • Adenoviridae / genetics*
  • Bioterrorism*
  • Communicable Disease Control*
  • Genetic Therapy*
  • Genetic Vectors
  • HIV Infections / genetics
  • HIV Infections / therapy*
  • HIV-1 / genetics
  • Humans
  • Viral Proteins / genetics
  • Viral Proteins / immunology

Substances

  • AIDS Vaccines
  • Viral Proteins