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, 510 (3), 223-8

Anti-allodynic and Anti-Hyperalgesic Effects of Nociceptin Receptor Antagonist, JTC-801, in Rats After Spinal Nerve Injury and Inflammation

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Anti-allodynic and Anti-Hyperalgesic Effects of Nociceptin Receptor Antagonist, JTC-801, in Rats After Spinal Nerve Injury and Inflammation

Hisayoshi Tamai et al. Eur J Pharmacol.

Abstract

The effects of nociceptin/orphanin FQ (N/OFQ) peptide receptor antagonist JTC-801 on allodynia and hyperalgesia were examined in rats in order to explore the involvement of N/OFQ system in these pathological pain states. Tactile allodynia induced by L5/L6 spinal nerve ligation was reversed by both systemic (3-30 mg/kg) and spinal (22.5 and 45 pg) JTC-801 in a dose-dependent manner. Concerning hyperalgesia induced by formalin injection into the hindpaw, JTC-801 dose-dependently suppressed the second phase, but not the first phase, of the licking behavior. Furthermore, systemic JTC-801 reduced Fos-like immunoreactivity in the dorsal horn of the spinal cord (laminae I/II). In conclusion, N/OFQ receptor antagonist JTC-801 exerted anti-allodynic and anti-hyperalgesic effects in rats, suggesting that N/OFQ system might be involved in the modulation of neuropathic pain and inflammatory hyperalgesia.

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